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Chronic hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR in human endothelial cells

Abstract Olszewska-Pazdrak B, Hein TW, Olszewska P, Carney DH. Chronic…

Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation

Abstract A major adaptive pathway for hypoxia is hypoxic preconditioning…

Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury

Abstract Chaperones, especially the stress inducible Hsp70, have been studied…

Hypoxia alters the immunomodulatory response of mast cells following Staphylococcus aureus infection

Abstract Background: Although best known for their role in allergy…

Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1-dependent manner

Abstract Phagocytosis is the process by which microbial pathogens are…

Mechanisms of Hypoxic Regulation of Plasminogen Activator Inhibitor-1 Gene Expression in Keloid Fibroblasts

Abstract Keloids are an excessive accumulation of extracellular matrix. Although…

Differentiation of murine mast cells under physiological oxygen conditions

Abstract Mast cells (MCs) are important innate immune cells mediating…

Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of 2 integrin gene expression

Abstract Inflammatory responses are associated with significant changes in tissue…

Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose

Abstract Hypoxic regions within solid tumors harbor cells that are…

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